Flagyl Toxicity Signs

Posted by Doug T on February 02, 2002 at 11:04:30:

This was sent to me from a vet student friend who checked up on the issue. Just more things to think about.

"...not only Flagyl toxicity is rare, but there are characteristic signs of it. You'll ALWAYS see neurological signs- the toxicity that results is because of it crossing the blood-brain barrier at high enough concentrations to activate certain regions, especially those involving balance and coordination. Thus, you'll see ataxia, wandering around, loss of coordination, twirling, star-gazing and the like. It has been reported that there can be GI signs, but you'll only see it with the neurological cases. Both dogs and humans have reported overdose signs, but within 12 hours of discontinuance of the drug, all side effects abated. In no animals studied of any species, metronidazole has caused liver of kidney damage, blood dyscrasias, or any permanent effects (this includes species/individuals that are known to be more sensitive to metronidazole). Oh, one more thing, it's also been shown several times over to have poor oral absorbtion. Most of the drug just passes through the GI tract, thus being a great compound for treating enteritis"

Follow Ups:

• that is a total lie! dave f 02/02/02 (5)
  • Aspirin = analgesic, not NSAID jeremy 02/02/02 (0)
  • Whoa there, Doug T 02/02/02 (3)
    • Re: Whoa there, .....Reply Carl 02/02/02 (0)
    • Hey chameleon boy, are you a retard? jeremy 02/02/02 (1)
      • NSAIDs Roger 04/10/02 (0)

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: This was sent to me from a vet student friend who checked up on the issue. Just more things to think about. : "...not only Flagyl toxicity is rare, but there are characteristic signs of it. You'll ALWAYS see neurological signs- the toxicity that results is because of it crossing the blood-brain barrier at high enough concentrations to activate certain regions, especially those involving balance and coordination. Thus, you'll see ataxia, wandering around, loss of coordination, twirling, star-gazing and the like. It has been reported that there can be GI signs, but you'll only see it with the neurological cases. Both dogs and humans have reported overdose signs, but within 12 hours of discontinuance of the drug, all side effects abated. In no animals studied of any species, metronidazole has caused liver of kidney damage, blood dyscrasias, or any permanent effects (this includes species/individuals that are known to be more sensitive to metronidazole). Oh, one more thing, it's also been shown several times over to have poor oral absorbtion. Most of the drug just passes through the GI tract, thus being a great compound for treating enteritis"

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